https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 The enigma of the adrenarche: identifying the early life mechanisms and possible role in postnatal brain development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45257 Wed 26 Oct 2022 15:32:17 AEDT ]]> Loss of neurosteroid-mediated protection following stress during fetal life https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24307 A receptor subunits that normally heighten neurosteroid sensitivity. These stressors also result in altered placental allopregnanolone metabolism pathways. These findings suggest that reduced neurosteroid production and action in the perinatal period may contribute to some of the adverse neurodevelopmental and behavioural outcomes that result from these pregnancy compromises. Studies examining perinatal steroid supplementation therapy with non-metabolisable neurosteroid analogues to improve these outcomes are warranted.]]> Thu 21 Oct 2021 12:51:39 AEDT ]]> Cerebellar changes in guinea pig offspring following suppression of neurosteroid synthesis during late gestation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32953 A receptor subunit composition, which may further limit neurosteroid action. The objective of this study was to determine the effects of suppression of allopregnanolone levels on the markers of development and functional outcome. Pregnant guinea pigs were treated with finasteride at a dose (25 mg/kg maternal weight) shown to suppress allopregnanolone between 60 days of gestation until delivery (term ~71 days). The cerebella from neonates, whose mothers were treated with finasteride or vehicle during pregnancy, were collected at postnatal age 8. Pups that received finasteride displayed significantly greater glial fibrillary acid protein area coverage and reduced GABAA receptor a α₆-subunit messenger RNA within the cerebellum than pups that were exposed to vehicle. These findings indicate that loss of neurosteroid action on the foetal brain in late gestation produces prolonged astrocyte activation and reductions in GABAA receptor a α₆-subunit expression. These changes may contribute to the long-term changes in function associated with preterm birth.]]> Thu 16 Aug 2018 13:35:57 AEST ]]> Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32952 Thu 16 Aug 2018 13:35:51 AEST ]]> Models of perinatal compromises in the guinea pig: their use in showing the role of neurosteroids in pregnancy and the newborn https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29502 Sat 24 Mar 2018 07:29:45 AEDT ]]>